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Scientific Summary

Amerdon™ Research in Biomolecular Therapy

Contents

Introduction

Discussion: Part 1: Biomolecular Therapy
Foundation of knowledge.

Discussion: Part 2: Accelerated Osteogenesis Project
An overview of the health benefits and infield case studies utilizing Rapid Response®.

Discussion: Part 3: Amerdon™ Hematology Study
A non-toxicity control study.

Reprinted with permission from Dormello Equine Nutrition Inc. Publications

Summary

Introduction

In the history of nutritional science, substances have been overlooked as that class act of complex plant protein, carbohydrates, starch and fats. A stabilizing of specifically joined complex substances is the key link in the basic process of metabolism so that energy and balance are provided chemically in living, growing cells. Thus, biomolecular therapy is the living essence of the plant kingdom working from a high level of biological sophistication via energy transfer at the level of animal biology.

Amerdon™ research on this topic is summarized within the text of this paper. The information is discussed in three parts: (1) A summary of the foundation knowledge supporting research and development; (2) an overview of the health benefits and the infield case studies of the resulting product, Rapid Response®; and (3) a non-toxicity report based on complete hematology profiles.

Discussion: Part 1: Biomolecular Therapy

Click the thumbnail to view Electro Chemical Assay.

The polyaionic components of cell walls and extra cellular and intracellular fluids ion exchange properties, are involved in the transfer of nutrients and electrolytes through cell walls. When the cells receive its allotment of life sustaining nutrients, which enables cleansing and oxygenation on the cellular level to take place, the stage is set for the proper, if not enhanced, maintenance and repair processes.

During the digestive process, when foods are broken down into building blocks for the body's mass and energy, protein is reduced to their amino acids, fat is reduced to fatty acids and carbohydrates are reduced to glucose. It is these simplest of materials, the acids and glucose, that are allowed to enter the bloodstream where they pass into the sphere of fluid energy.

These nutrients must first nourish the wall of the cell. This job is performed by certain amino and fatty acids which group together (combine) and form a new mass called "lipoprotein." It is the lipoprotein that strengthens and repairs the cell wall and will even completely rebuild it if necessary. Next, the remainder of the fatty acids and the glucose pass osmotically through the pores of the cell wall to be oxidized (burned-up in the protoplasm for energy). This process requires oxygen which enters the cell in the same manner as the other nutrients through the porous lipoprotein wall. How these micronutrients are driven in their forward movement through the body's elaborate transport system to accomplish their osmotic passage into the rotating energy of the cell and how the cell continues the transformation is called "metabolism"--which is the creation of mass and energy out of the simplest micronutrients.

Protein: The food molecule elements in plant protein are carbon, hydrogen, oxygen, sulfur, iron, phosphorus and nitrogen. Nitrogen is the most important element of the seven as it is this element that yields nucleic acids and amino acids to build body protein. Without these acids, it would be impossible for cells to build, maintain and repair any bodily tissue. Substantial nutrients must be chosen based on the highest biological availability containing the most efficient use of plant protein. This will intensify and secure the completion of the animal's victory over toxins, viruses and bacteria invading the cells and allow for the stimulation of cell and tissue repair processes.

Fats: During digestion fat is emulsified in the stomach by bile and converted into fatty acids and glycerol. Then these two substances are recombined upon absorption to form neutral fat which is oxidized to furnish energy. It also may be stored as body fat for reserve or combine with protein to form complex substances of body tissues. Fat can not be digested without the required enzymes.

Carbohydrates: There are three phases to the conversion of carbohydrate to energy. All three phases take place within the framework of the salivary glands, liver, pancreas and small intestines. Each of these organs contributes a specific enzyme, or group of enzymes, to the breaking down of the carbohydrate from the tough polysaccharide ancestor buried in food to the simple monosaccharide base newly delivered into the blood stream.

Carbohydrates, and the digestion of carbohydrates, are those foods in which the combination of the three elements carbon, hydrogen, and oxygen exist and are linked in the same ratio as they are in water. During digestion, carbohydrates must be reduced to a monosaccharide to pass into the blood stream. There are basically three generations of sugars in the saccharide family:

• Polysaccharides (poly = many)
• Disaccharides (di = twice one)
• Monosaccharides (mono = one)

Further, minerals are a group of basic nutrients which extend their life-giving influence into every bone, muscle, nerve, tendon, organ, tissue and cell in the body. The presence of calcium, phosphorus, magnesium, sodium, potassium, and iron are all major conditions of our interior environment.

Bone remodeling undergoes a constant cycle of resorbption and formation. Mucopolysaccharides enhance the ability of "osteoclasts" and "osteoblasts" to perform on a higher level (mend faster and better). Osteoclasts are bone resorbing cells that originate in the bone marrow. These precursor cells from the blood collect at bone resorbtion sites and fuse to form multi-nucleatic osteoclasts which erode (aggravate) the damaged area--but with the good intention of preparing the area for repair by the osteoblasts. The osteoblast precursor cells migrate to areas where bone has been eroded by the osteoclasts and begin laying down collagen and minerals in the formation of new bone in the cavities.

The fortifying process of osteoclasts and osteoblasts clean up and lay down new bone in cavities to complete the process of resorption and formation of new bone. However, given nutrients which have been properly stabilized and introduced to the animal, these biological mechanisms can be accelerated. Further, Rapid Response is designed to support bone renewal and not ossify joints. There is no loss of flexibility.

In order to continuously maintain an environment worthy to support this transformation within the cells, it is up to us to provide the system with its required energy source--and those sources must be balanced. An overabundance or the neglect of any one of them will cause problems. "Balance to maintain balance;" nature's incontrovertible law.

Mineral Chelation

To make new RBC's (red blood cells), bones must be supplied with calcium, magnesium, manganese, zinc, copper, and sulfur by way of an amino acid carrier which, according to the most recent discoveries, constitute the most efficient chelates. Example: The increased efficiency of a mineral when it is chelated with lysine to serve as a building block of a new matrix structure, or with methionine which is instrumental in furnishing sulfur as a precursor of collagen formation. The very formation of the life-carrying blood cell itself is dependent on the enzymatic, catalyzing fuctions of the minerals.

To retain biological longevity and structural health is fundamentally to serve its principle of balance and exchange. This osmosis of ions moving through cell membranes, from areas of lesser ionic concentration to areas of greater ionic concentration, requires energy from sources including specifically introduced nutrients. And so, permeating the cells, tissues and organs, flows the tide of life supporting ions.

Discussion: Part 2: Accelerated Osteogenesis Project

Conventional medicine, human or veterinary, has been doing battle with disease and injury conditions by placing its emphasis on crisis intervention using traditional therapy methods which primarily involve surgery and pharmaceutical drug treatment. To paraphrase Maslow, "If all you're trained to use is a hammer, the whole world looks like a nail."

However, there comes a time when a significant scientific breakthrough occurs and everything changes forever. Whereas the economic and personal impact of fractures and tendon damage is staggering, the objective behind the years of research and infield studies surrounding the Accelerated Osteogenesis Project was to discover a non-invasive approach of accelerating the biological mechanisms responsible for the health of bones, tendons, and soft tissues following trauma induced injuries.

Rapid Response® involves the oral administration of a concentrated liquid, as well as the concurrent topical application of the same liquid as an astringent utilizing a soft wrap pressure bandage. The topical application helps to increase the body temperature and circulation of the product to that area. Structural support statements include:

• Rapid Response strengthens collagen and elastin proteins by affixing to the micro fibrils, or filaments, which support the formation of hydrogen bridges balancing the healthy condition of tissues and bone matrices.
• Toxins that are released from congested lymphatics and form in the damaged area as a result of injury represent free radical debris. As a potent antioxidant--with superior ionization attributes which neutralize the oxidizing effect of both positive and negative free radicals--Rapid Response™ nutritionally supports the animals defense system in removing the toxins and neutralizing the pro-oxidative affects of cellular metabolism.
• Rapid Response assists in the formation of synovial fluid, an important factor in maintaining skeletal and soft tissue health. Rapid Response also contains certain compounds that act to prevent the release of histamine by forming a barrier around cell membranes to block the entry of destructive enzymes onto the cell's lysozome where histamine is contained. The release of histamine is known to increase capillary permeability, resulting in the leakage of serous fluid from cellular tissues.
• Rapid Response provides protection to vascular walls by activating the metabolism of collagen and elastin which strengthens vascular membranes and helps to nutritionally support the animal's body in safeguarding against cellular destruction.
• Rapid Response converts lipoproteins into high energy fuel.
• The naturally occurring minerals in Rapid Response are chelated and positively ionized which allow for greater absorption. Likewise, they are organically bound to insure proper distribution of calcium which further supports the maintenance of a healthy skeletal system.

Traditional protocol for cases involving, for example, distal green stick type fractures of the forelimb metacarpal or cannon bone of a horse, would expect to realize satisfactory clinical resolution in 10 to 14 months, at which time a return to normal training would be attempted. However, the long term outcome is unpredictable, particularly in terms of site complications.

The animals that participated in the infield studies were all obtained from their owners for research purposes at a variety of time gaps following their injury. In all cases, treatment was supervised by an attending veterinarian. There were "no failures." "No failures" means that in each and every case, whereby Rapid Response was utilized, the healing process took place completely and much more rapidly than any known conventional method of treatment for such injuries. These conclusions are demonstrated with x-ray and ultrasound diagnosis. Further, "no failures" means that the micro architecture of the injured bone following treatment resulted in quality density renewal, and in each and every case, no indications were found, or have been reported after an extended period of time, of site complications common to fracture injuries such as calcium build-up and arthritis.

Case Models

Montclair, a retired race horse stud, got caught in a metal feeder sustaining a compound fracture of the lower jaw. Swelling and abscess occurred during the week prior to diagnosis. The attending vet performed surgery and wired the left side of the mandible. Immediately following surgery Rapid Response was introduced into the diet. Within three days Montclair was eating again without distress, and within 90 days final x-rays were taken indicating that 100% healing had occurred.

Super Strike incurred a non-displaced condylar fracture that extended into the ankle joint during a training workout at Hollywood race track. The horse remained untreated for one month. Rapid Response was then utilized as recommended by the attending vet. X-rays indicated complete recovery within 90 days. After three years, 100% flexing of the ankle remains and the joint is clear.

Cone Hata (a 1,200 pound thoroughbred injured going out of the gate), and On the Lawn (winner by six lengths during his maiden race and subsequently injured during training), both received severe non-union sesamoid fractures. With no known conventional treatment available, both horses were put out to pasture as recommended by the attending veterinarian. After 18 months they were again x-rayed--no healing had occurred. Both thoroughbreds were put on a daily schedule of Rapid Response. During the following four and one half months both horses returned to 100% of their pre-injured condition as confirmed by x-rays. Also, all site complications were cleared. Cone Hata and On the Lawn were returned to a daily training schedule.

Fisher was injured with a non-displaced condylar fracture of the right rear leg cannon bone during a training workout. Treatment began 1 day after the injury. By day 37 the injury was 100% healed. The horse swam for two weeks, trained for two weeks, and then went back onto the track to win his first race.

Three Mikes suffered a displaced lateral condylar fracture of the distal metacarpal #3 of the left foreleg during a race. The animal was on the way to slaughter when spared for Amerdon™ Rapid Response research. When final x-rays were taken following 31 days of being on the Rapid Response program, Three Mikes was over 80% healed (at that time, the owners chose to move the horse and the animal did not go back to racing).

Star Something was injured with bilateral front ruptured tendons in both legs during a race. Forty eight days following the injury, the animal began daily doses of Rapid Response. With in 74 days 100% healing had taken place.

Kings Lock was injurred during a race with a ruptured superficial tendon along the palmar pastern. Fifty-five days following the injury the animal began daily doses of Rapid Response. It took 14 days for 100% healing.

Expensit suffered two torn (inside and out) suspensory ligaments and a ruptured tendon. The injury visibly expanded the width of the right front leg by about 1/2 inch on either side. After 90 days of Rapid Response, the leg size had returned to normal (unprecedented for this type of injury), and the injury was confirmed by the attending vet using ultra sound to be 100% healed. The horse was returned to training.

Michael's Flyer received a severe race-related saucer fracture to the right front cannon bone. He was stalled for two and one half months. During that time no healing of the fracture took place, complicated by calcification occurring protruding to the exterior. Within four weeks of a daily program of Rapid Response the calcium formations were eradicated and the fracture completely healed. Michael's Flyer returned to win five races and to become stakes placed.

Dom, a dresage horse, endured a ruptured tendon during training. Utilizing Rapid Response the horse was light training within 45 days. Dom is now fourth in the nation.

Particularly when there is an injury or chronic condition whereby traditional treatments can not be practiced, then Rapid Response becomes a favorable alternative. The product also mitigates pain.

Discussion: Part 3: Amerdon™ Hematology Study

Click the thumbnail to view Cell Growth Study.

Under the direction of Dr. T. G. Fourziano and attending veterinarian, A. McCabe, DVM, 40 in-training thoroughbred performance horses, ages two to five years, were monitored for a period of 10 weeks at the San Luis Rey Downs training facility in Southern California. Twenty animals represented a control group; twenty animals were given recommended doses of Amerdon™ Rapid Response® daily. Weekly, veterinary general condition reports, as well as complete blood profiles utilizing forty-five standard scientific markers (Hematology CBC) to measure the internal health of the animal were recorded.

On the topic of non-toxicity, which was the primary interest of the study, Rapid Response was shown to be 100% safe with no contraindications. Further, and as a practical matter, the results of this study also represented the necessity for specifically designed increased nutrition when the animal's health is suffering, or has the potentiality to suffer, due to viral or bacterial infections. During the time and place of this study, viral and bacterial health problems were realized by animals throughout the entire facility. Out of the remaining sixteen of the original 20 horses involved in the control group, 62% were put on antibiotcis. The control group lost a total of 85 days of training. In contrast, all of the original 20 animals receiving daily doses of Rapid Response remained healthy with no treatments recommended--and not one training day was interrupted.